Integrin αvβ5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function
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Integrin v 5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function
Increased lung vascular permeability is an important contributor to respiratory failure in acute lung injury (ALI). We found that a function-blocking antibody against the integrin v 5 prevented development of lung vascular permeability in two different models of ALI: ischemia-reperfusion in rats (mediated by vascular endothelial growth factor [VEGF]) and ventilation-induced lung injury (VILI) i...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2007
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2006-0238oc